A7824
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A7824
Sigma
6-Aminocaproic acid
SigmaUltra, ≥99%
| Synonym: | ε-Aminocaproic acid, 6-Aminohexanoic acid, EACA |
| CAS Number: | 60-32-2 |
| Linear Formula: | H2N(CH2)5CO2H |
| Molecular Weight: | 131.17 |
| Beilstein Registry Number: | 906872 |
| EC Number: | 200-469-3 |
| MDL number: | MFCD00008238 |
| PubChem Substance ID: | 24278238 |
Description
| Biochem/physiol Actions | Lysine analog. Promotes rapid dissociation of plasmin, thereby inhibiting the activation of plasminogen and subsequent fibrinolysis.1,2 Reported to inhibit plasminogen binding to activated platelets.3 An early report indicated that it inhibits the activation of the first component of the complement system.4 Binds and inactivates Carboxypeptidase B.5 |
Properties
| grade | SigmaUltra |
| assay | ≥99% |
| total impurities | ≤0.005% Phosphorus (P) |
| ≤0.1% Insoluble matter | |
| ign. residue | ≤0.1% |
| mp | 207-209 °C (dec.)(lit.) |
| solubility | H2O: 0.5 M at 20 °C, clear, colorless |
| anion traces | chloride (Cl-): ≤0.05% |
| sulfate (SO42-): ≤0.05% | |
| cation traces | Al: ≤0.0005% |
| Ca: ≤0.005% | |
| Cu: ≤0.0005% | |
| Fe: ≤0.0005% | |
| K: ≤0.005% | |
| Mg: ≤0.001% | |
| NH4+: ≤0.05% | |
| Na: ≤0.02% | |
| Pb: ≤0.001% | |
| Zn: ≤0.0005% | |
| Gene Information | human ... PLG(5340) |
| rat ... Ppm1a(24666) |
Safety
| Personal Protective Equipment | dust mask type N95 (US), Eyeshields, Gloves |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 2 |
| RTECS | MO6300000 |
References
| Cited Reference | 1. Humphries, J.E., et al., Fibrinogenolytic and fibrinolytic activity of cell-associated plasmin,. Arterioscler. Thromb. 13, 48-55, (1993) |
| 2. Krishnamurti, C., et al., Inhibitory effects of lysine analogues on t-PA induced whole blood clot lysis. Thromb. Res. 73, 419-430, (1994) | |
| 3. Adelman, B., et al., Plasminogen interactions with platelets in plasma. Blood 72, 1530-1535, (1988) | |
| 4. Soter, N.A., et al., Inhibition by ε-aminocaproic acid of the activation of the first component of the complement system,. J. Immunol. 114, 928, (1975) | |
| 5. Dessaint, J.P., et al., Catheptic carboxypeptidase B as a major component in "T-cell activating factor" of macrophages. J. Immunopharmacol. 1, 399-414, (1979) | |
| Merck | Merck 13,431 |
| Beilstein | Beil. 4,IV,2695 |
| reference | Aldrich MSDS 1, 67:B / Corp MSDS 1 (1), 149:B / FT-IR 2 (1), 919:B / FT-IR 1 (1), 578:D / IR-Spectra (3), 345:F / IR-Spectra (2), 308:A / NMR-Reference 2 (1), 490:C / RegBook 1 (1), 659:G / Sax 6, 205 / Sigma FT-IR 1 (1), 33:B / Structure Index 1, 97:B:8 |
